In a normal version, if you tap on the Opera icon on the bottom left, you will see a small menu with settings and other basic options. In opera beta version 65, that icon got changed to "your profile" and from there you can access a wide range of different options and settings.
From there you can easily personalise your browser, turn on and off one of four toggles (VPN, Data Saving, Ad-blocking and night mode). Now, this is a slider instead of a pop-up menu and you can expand it to get access to additional settings. It should make it easier to control because now you will need fewer clicks in order to get access to these menus.
Thanks to the TestingCatalog reader for the tip!